Wales will embark on a six-day training camp in North Wales, culminating with a game against RGC.
The game is part of preparations for a two-test tour against Tonga and Samoa this summer.
Robin McBryde, will put the Welsh squad through their paces against the Principality Premiership side in Colwyn Bay on Friday June 2.
“We are delighted to be heading to North Wales this summer,” said McBryde.
“The camp will be the first week the whole squad for the tour convene after their respective regional and club commitments so we will be looking to hit the ground running.
“We received a fantastic welcome to North Wales on our last visit as part of our World Cup preparation in 2015 and I’m delighted that we are able to return once again.
“The North Wales community have taken Wales U20 under their wing so it’s great to be able to take the national squad back to North Wales.
“The facilities are great at Parc Eirias and will provide us with the exactly what we are looking for in terms of a training camp.
“Not only will the match be hugely important for the squad off the field, it will be a great spectacle to see RGC line-up against the Welsh side and a huge opportunity for all those players.”
RGC head coach Mark Jones said: “This fixture is a fantastic opportunity for RGC and North Wales rugby to help Wales prepare for their important up and coming tour. Perhaps even more importantly for me, it shows how far we’ve come as a development region.
"Players who have come right through the pathway in North Wales will have the ultimate honour – the chance to play against our national team, demonstrating the pathway now in place for North Wales players to develop to a very high level.”
Wales will head to Colwyn Bay on Sunday May 28 to train at Parc Eirias. Full details of the fixture will be announced in due course.